威廉体育

陈毅歆

陈毅歆 教授

职务:

电子邮件:yxchen2008@xmu.edu.cn

办公地点:厦门大学翔安校区椭圆楼321室

主要研究领域:

陈毅歆 教授 博导

CHEN Yixin,Ph.D.,Professor

国家传染病诊断试剂与疫苗工程技术研究中心单抗组组长

厦门大学生物安全三级实验室(筹)副主任

Email:yxchen2008@xmu.edu.cn

Tel:+86-592-2181661

简历 (Education and Work experience):

2008年,厦门大学生物化学与分子生物学专业,博士学位;

2009年至今,厦门大学生命科学威廉体育,助理教授/副教授/教授;

2011年至今,厦门大学公共卫生威廉体育,助理教授/副教授/教授。

Ph.D. 2008, Xiamen University, Biochemistry and Molecular Biology;

Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2009 to Present;

Assistant Professor/Associate Professor/Professor, School of Public Health, Xiamen University, 2011 to Present.

研究领域(Research Area):

本课题组研究领域为抗体与疫苗,主要涉及两个研究方向:其一,从事流感病毒、冠状病毒和疱疹病毒等相关病毒性传染病的基础研究与应用转化研究,主要依托成熟的小鼠、大鼠、兔和鸡禽等单克隆抗体技术平台筛选出识别新型病毒靶标/表位的功能性抗体,并指导预防性疫苗、治疗性抗体药物和免疫诊断试剂盒的研发,研制的鼻喷流感载体新冠疫苗已在我国获批紧急使用。其二,从事肿瘤诊治领域研究,基于“以毒攻毒”的策略,将特定病毒经基因编辑改造发展成可治疗癌症的新型溶瘤病毒药物;基于功能抗体的正向筛选技术发现新型肿瘤特异性靶标,以指导新型肿瘤治疗性抗体药物和肿瘤特异诊断试剂研发。

Antibody & Vaccine. Our research focuses on two major areas: One is the basic, applied and translational researches for understand and control of infectious diseases such as influenza virus, coronavirus, herpesvirus associated disease. Functional monoclonal antibodies targeting novel epitopes of viruses were identified using mouse, rat, rabbit, and chicken antibody techniques. Such epitopes and antibodies can be used as promising candidates for the development of vaccines, therapeutic agents, and diagnostic kits against specific viruses. A live-attenuated influenza virus-based intranasal COVID-19 vaccine we developed has been approved for emergency use in China. The other is the cancer research, including the development of oncolytic virus for cancer therapy and the discovery of novel tumor targets for cancer diagnosis and therapy.

代表性论文(Selected Publications)(# co-first author, * Corresponding author):

1. Chen J, Wang P, Yuan L, Zhang L, Zhang L, Zhao H, Chen C, Wang X, Han J, Chen Y, Jia J, Lu Z, Hong J, Lu Z, Wang Q, Chen R, Qi R, Ma J, Zhou M, Yu H, Zhuang C, Liu X, Han Q, Wang G, Su Y, Yuan Q, Cheng T, Wu T*, Ye X*, Zhang T*, Li C*, Zhang J*, Zhu H*, Chen Y*, Chen H*, Xia N*. A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2. Science Bulletin. 2022 Jul 15;67(13):1372-1387.

2. Zhu F*, Zhuang C, Chu K, Zhang L, Zhao H, Huang S, Su Y, Lin H, Yang C, Jiang H, Zang X, Liu D, Pan H, Hu Y, Liu X, Chen Q, Song Q, Quan J, Huang Z, Zhong G, Chen J, Han J, Sun H, Cui L, Li J, Chen Y*, Zhang T*, Ye X*, Li C*, Wu T*, Zhang J*, Xia NS*. Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials. Lancet Respiratory Medicine. 2022 Aug;10(8):749-760.

3. Li T, Chen J, Zheng Q, Xue W, Zhang L, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y, Chen Y*, Li S*, Xia N*. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nature Communications. 2022 Sep 2;13(1):5182.

4. Wang G, Zha Z, Huang P, Sun H, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q, Chen Y*, Li S*, Xia N*. Structures of pseudorabies virus capsids. Nature Communications. 2022 Mar 22;13(1):1533.

5. Zhang X*, Hong J, Zhong L, Wu Q, Zhang S, Zhu Q, Chen H, Wei D, Li R, Zhang W, Zhang X, Wang G, Zhou X, Chen J, Kang Y, Zha Z, Duan X, Huang Y, Sun C, Kong X, Zhou Y, Chen Y, Ye X, Feng Q, Li S, Xiang T, Gao S, Zeng MS, Zheng Q*, Chen Y*, Zeng YX*, Xia N*, Xu M*. Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2202371119.

6. Hong J, Wei D, Zhong L, Wu Q, Chen K, Zhang W, Yang Y, Chen J, Xia N, Zhang X*, Chen Y*. Glycoprotein B Antibodies Completely Neutralize EBV Infection of B Cells. Frontiers in Immunology. 2022 May 27;13:920467.

7. Hong J, Zhong L, Zheng Q, Wu Q, Zha Z, Wei D, Chen H, Zhang W, Zhang S, Huang Y, Chen K, Chen J, Li S, Zeng MS, Zeng YX, Xia N, Zhang X*, Xu M*, Chen Y*. A Neutralizing Antibody Targeting gH Provides Potent Protection against EBV Challenge In Vivo. Journal of Virology. 2022 Apr 27;96(8): e0007522.

8. Wang X*, Yin X, Zhang B, Liu C, Lin Y, Huang X, Li Y, Shen C, Zheng W, Fu G, Chen J, Wen Y, Zhang W, Pan BS, Fang M, Zheng Z, Zhang Z, Yuan Q, Fu G, Li S, Zhang J, Chen Y*, Xia N*, Zhao Q*. A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerging Microbes & Infections. 2022 Dec;11(1):914-925.

9. Zhang L, Chen J, Shen C, Wang G, Lu Z, Zeng D, Gao Y, Chen H, Xia N, Chen Y*. Vaccination with Deglycosylated Modified Hemagglutinin Broadly Protects against Influenza Virus Infection in Mice and Ferrets. Vaccines. 2022 Aug 11;10(8):1304.

10. Zeng D, Xin J, Yang K, Guo S, Wang Q, Gao Y, Chen H, Ge J, Lu Z, Zhang L, Chen J, Chen Y*, Xia N. A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection. Viruses. 2022 Jun 14;14(6):1305.

11. Chen Y, Shen C*, Chen J, Chen J, Chen F, Zhang L, Liu X, Chen S, Xue S, Liu Y, Tang J, Yuan Q, Chen Y*, Luo W*, Xia N. Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells. Virologica Sinica. 2022 Aug;37(4):619-622.

12. Wang G, Chen R, Huang P, Hong J, Cao J, Wu Q, Zheng W, Lin L, Han Q, Chen Y*, Xia N. Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo. Antiviral Research. 2021 Feb;186: 105014.

13. Hong J, Wei D, Wu Q, Zhong L, Chen K, Huang Y, Zhang W, Chen J, Xia N, Zhang X, Chen Y*. Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region. Viruses. 2021 Nov 28;13(12):2380.

14. Wang G, Huang P, Hong J, Fu R, Wu Q, Chen R, Lin L, Han Q, Chen H, Chen Y*, Xia N. Establishment of a rapid ELISPOT assay for influenza virus titration and neutralizing antibody detection. Journal of Medical Virology. 2021 Jun;93(6):3455-3464.

15. Hong J, Wang Q, Wu Q, Chen J, Wang X, Wang Y, Chen Y*, Xia N. Rabbit Monoclonal Antibody Specifically Recognizing a Linear Epitope in the RBD of SARS-CoV-2 Spike Protein. Vaccines. 2021 Jul 28;9(8):829.

16. Shen C, Zhang M, Chen Y, Zhang L, Wang G, Chen J, Chen S, Li Z, Wei F, Chen J, Yang K, Guo S, Wang Y, Zheng Q, Yu H, Luo W, Zhang J, Chen H, Chen Y*, Xia N. An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency. Theranostics. 2019 Jan 1;9(1):210-231.

17. Cao J, Zhong N, Wang G, Wang M, Zhang B, Fu B, Wang Y, Zhang T, Zhang Y, Yang K, Chen Y*, Yuan Q*, Xia N. Nanobody-based sandwich reporter system for living cell sensing influenza A virus infection. Scientific Reports. 2019 Nov 4;9(1):15899. doi: 10.1038/s41598-019-52258-7.

18. Chen J, Yang K, Zhang M*, Shen C, Chen J, Wang G, Huang S, Zhang M, Xiong H, Chen H, Chen Y*, Xia N. Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program. Clinical Microbiology and Infection, 2018 Mar;24(3):289-294.

19. Woo PCY #, Lau SKP #, Chen Y#, Wong EYM, Chan KH, Chen H, Zhang L, Xia N, Yuen KY. Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin. Emerging Microbes & Infections. 2018 Mar 7;7(1):18.

20. Lin Q #, Li T #, Chen Y #, Lau SY, Wei M, Zhang Y, Zhang Z, Yao Q, Li J, Li Z, Wang D, Zheng Q, Yu H, Gu Y, Zhang J, Chen H, Li S, Xia N. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. Journal of Virology. 2018 Aug 16;92(17).

21. Shen C, Chen J, Li R, Zhang M, Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y*, Xia N*. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Science Translational Medicine. 2017 Oct 18;9(412). (Peter Palese comments in Nature, Highlighted by Nature Reviews Drug Discovery, Highlighted by “知识分子)

22. Chen Y, Chan KH, Hong C, Kang Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau SK, Woo PC. A highly specific rapid antigen detection assay for on-site diagnosis of MERS. Journal of Infection. 2016 Jul;73(1):82-4.

23. Zhang P #, Chen Y #, Zeng Y #, Shen C, Li R, Guo Z, Li S, Zheng Q, Chu C, Wang Z, Zheng Z, Tian R, Ge S, Zhang X, Xia NS, Liu G, Chen X. Virus-mimetic nanovesicles as a versatile antigen-delivery system. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6129-38.

24. Chen Y, Chan KH, Kang Y, Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK, Woo PC. A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections. 2015 Apr;4(4):e26. (Highlighted by Nature.com)

25. Gui X, Li R, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*. An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2. Virology,2014,464-465:11-20.

26. Gui X, Ge P, Wang X, Yang K, Yu H, Zhao Q, Chen Y*, Xia N*. Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus. Journal of Medical Virology,2014,86:995-1002.

27. Chen Y #, Li C #, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine,2013,31:425-30.

28. Wu WL, Lau SY, Chen Y, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research,2012,93:144-153.

29. Chen Y #, Zheng Q #, Yang K, Zen F, Lau S-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N. Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection,2011,17:1347-1349.

30. Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N. Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy,2011,55:1349-1357.

31. Chen Y, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N. A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. Journal of Virological Methods, 2009,167:100-102.

32. Chen Y #, Qin K #, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N. Broad Cross-Protection against H5N1 Avian Influenza Virus Infection by Means of Monoclonal Antibodies that Map to Conserved Viral Epitopes. Journal of Infectious Diseases,2009,199:49-58.

33. WL Wu #, Chen Y #, Wang P, Song W, Lau SY, Rayner JM, Smith GJD, Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. Journal of Virology, 2008,82:1798-1807.

34. Chen Y, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang. Evaluation of a rapid test for detection of H5N1 avian influenza virus. Journal of Virological Methods,2008,154:213-215.

荣誉、奖励及参加学术团体的情况(Honors and award):

1. 国家自然科学基金重大研究计划培育项目,基于减毒流感病毒载体的流感和新冠肺炎通用疫苗的免疫保护机制研究,120万,2021,项目主持

2. 福建省科技重大专项项目,新型冠状病毒候选疫苗及质量控制方法研究,350万,2021,项目主持

3. 国家自然科学基金面上项目,CDCA3调控伪狂犬病毒溶瘤疗效的分子机制研究,55万,2021,项目主持

4. 福建省自然科学基金重点项目,鼻喷流感病毒载体新冠肺炎疫苗的免疫保护机制研究,40万,2021,项目主持

5. 国家重点研发计划项目,生物大分子胞内递送系统的研究,300万,2020,项目主持

6. 国家自然科学基金面上项目,甲型流感病毒血凝素头部区跨亚型广谱中和抗体的作用机制研究,56万,2019,项目主持

7. 国家自然科学基金面上项目,基于广谱中和单抗的通用型流感疫苗设计及其结构基础研究,60万,2017,项目主持

8. 国家自然科学基金面上项目,人肠道病毒71型构象性中和表位的确定及其诱导抗病毒免疫保护应答机制研究,50万,2014,项目主持

9. 国家自然科学基金青年项目,H5N1禽流感病毒血凝素广谱中和表位的结构研究,20万,2010,项目主持

10. 全国抗击新冠肺炎疫情先进集体奖,鼻喷流感病毒载体新冠肺炎疫苗和新冠病毒诊断试剂的研发,2020,

11. 福建省科技进步二等奖,流感广谱表位的发现及流感抗原免疫诊断试剂的研制与应用,2018

12. 厦门市科技进步二等奖,流感系列免疫诊断试剂的研发与应用,2018

13. 求是杰出科技成就集体奖,为原核表达类病毒颗粒疫苗研究做出突出贡献的科研团队,2015

14. 福建省科技进步奖一等奖,手足口病系列免疫诊断试剂的研究与应用,2015

15. 厦门市科技进步奖二等奖,手足口病系列免疫诊断试剂的研究与应用,2014

16. 厦门市科技进步奖三等奖,口岸适用性甲型流感监测技术创新研究与应用,2014

17. 北京市科技进步三等奖,人类免疫缺陷病毒(HIV)抗体快速诊断试剂,2003

18. 国家卫健委第三届病原微生物实验室生物安全评审专家委员会,2021

19. 中国医药生物技术协会生物安全专业委员会第三届委员会委员,2022

20. 科技部高等级病原微生物实验室生物安全审查委员会委员,2023

21. 福建省免疫学会会员,2020

22. 福建省高层次人才(A类),2021

23. 获国内外发明专利授权33件(2022 update)

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